|Profound Inhibitory and Apoptotic Effects of Histone Deacetylase Inhibitor Valproic Acid on Different Cancers|
|Masumeh Sanaei1, Fraidoon Kavoosi1|
|1Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran|
CJMB 2019; 6: 441–448
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Keywords : Valproic acid, Molecular mechanism, Cancer
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Objectives: Histone acetylation is determined by a balance between the activities of the enzymes that are involved in the histone modifcations, including histone deacetylases (HDACs) and histone acetyltransferases which affect gene expression and play a signifcant role in carcinogens. Valproic acid (VPA) belongs to the HDAC inhibitor family which inhibits HDAC
Methods: For this review, an online search of different sources such as ISI, PubMed, and Scopus resulted in fnding the articles correlated with mechanisms and pathways of VPA in different cancers.
Results: Based on these results, VPA may be a suitable agent and a good candidate for cancer treatment with multiple mechanisms of apoptosis induction.
Conclusions:Overall, VPA can protect against cancer by regulating histone modifcation and tumor suppressor gene reactivation.
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