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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2020, Vol 7, Issue 3
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Original Article
Determining the Efficacy of Some Hospital Disinfectants Against Methicillin-Resistant Staphylococci Isolated From Different Wards of an Educational Hospital
Seyed Ali Sajjadi1, Jalal Mardaneh2, Alireza Mohammadzadeh2, Roghye Hojjatpanah3, Hossein Nezami4, Mostafa Amiri5, Mehdi Ghasemi1
1Department of Environmental Health Engineering and Social Determinants of Health Research Centre, Faculty of Health, Gonabad University of Medical Sciences, Gonabad, Iran
2Department of Microbiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
3Student’s Research Committee, Department of Environmental Health Engineering, Faculty of Health, Gonabad University of Medical Sciences, Gonabad, Iran
4Department of Basic Sciences, Faculty of Medicine, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
5Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

CJMB 2020; 7: 355-361

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Keywords : MRAS, Staphylococcus epidermidis, Staphylococcus saprophyticus, Disinfectants, Nosocomial infections
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Objectives: Methicillin-resistant staphylococci are important causes of nosocomial infections. Due to the presence of these bacteria in hospitals as a significant challenge in hospital infection control, the identification of effective disinfectants against methicillin-resistant staphylococci is necessary. This study was designed to evaluate the effectiveness of common hospital disinfectants against methicillin-resistant staphylococci.

Materials and Methods: In this cross-sectional study, the effectiveness of 4 surface disinfectant cleaners (Deconex 50 AF, Microzed GP-H, Peranacid M1 and Surfocept quick) against methicillin-resistant staphylococci (10 Staphylococcus aureus, 10 Staphylococcus saprophyticus, and 55 Staphylococcus epidermidis) was evaluated using broth dilution method, disc diffusion assay, and cell viability assay.

Results: The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of Peranacid and Surfocept against the isolates were higher than those of Deconex and Microzed. The results of disk diffusion assay showed that staphylococcus strains exhibited greater inhibition zone diameter than other disinfectants at different concentrations of Deconex and Microzed. According to the results of cell viability assay, S. aureus, S. epidermidis, and S. saprophyticus isolates did not grow at three concentrations (0.5%, 1% and 2%) of Deconex, Microzed, and Peranacid, respectively.

Conclusions: Deconex and Microzed had more antimicrobial properties than the 2 other agents and methicillin-resistant staphylococcus isolates had a higher resistance to both Peranacid and Surfosept.


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Articles by Ali Sajjadi S
Articles by Mardaneh J
Articles by Mohammadzadeh A
Articles by Hojjatpanah R
Articles by Nezami H
Articles by Amiri M
Articles by Ghasemi M


Articles by Seyed Ali Sajjadi
Articles by Jalal Mardaneh
Articles by Roghye Hojjatpanah
Articles by Hossein Nezami
Articles by Mostafa Amiri
Articles by Mehdi Ghasemi

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