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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2019, Vol 6, Issue 4
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Original Article
The Effect of Hydroalchoholic Extract of Cinnamon zeylanicum on Oxidative Damages and Biochemical Change in Adult Rats With Polycystic Ovary Syndrome
Fariba Khodaeifar1, Seyyed Mohammad Bagher Fazljou1, Arash Khaki2, Mohammadali Torbati3, Elaheh Olad Saheb Madarek2, Amir Afshin Khaki4, Majid Shokoohi4,5, Amir Hossein Dalili6
1Department of Traditional Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
6Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2019; 6: 511–516

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Keywords : Cinnamon zeylanicum, Oxidative damages, PCOS, Hormones, Rat
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Abstract

Objectives: Polycystic ovary syndrome (PCOS) is known as one of the most usual hormone disorder in women of childbearing age. Accordingly, the aim of this research was to investigate the effect of hydroalchoholic extract of Cinnamon zeylanicum (CZ) on oxidative damages and biochemical change in adult rats with PCOS.

Materials and Methods: In our experimental research, 32 Wistar female rats were used (n=8 per group) including control group (G1), PCOS group without any therapy (G2), rats with PCOS that received a daily intake of hydroalcoholic extract (the 200 mg/kg/orally) of CZ for 2 weeks (G3), and the group with no PCOS while with a daily intake of the extract of CZ (200
mg/kg) for 2 weeks (G4). PCOS was induced by estradiol valerate with a single injection dose (16 mg/kg) intramuscularly. After 14 days, all animals were anesthetized with ketamine and xylazine, followed by obtaining the blood sample and using their plasma for checking the blood glucose, insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and testosterone. Finally, the ovaries of all animals were removed and fxed for assessing the histological damage.

Results: As regards the plasma levels of blood glucose, insulin, LH, FSH, and testosterone, a signifcant change was observed between G2 and G1 groups while G3 and G4 groups demonstrated a signifcant decline in terms of such parameters as compared to G2 group. In addition, the level of estrogen in the plasma decreased signifcantly in G2 as compared to G1
while in G2 and G1, it was signifcantly higher when compared to the PCOS group. Eventually, the number of follicles reduced in PCOS group while it indicated an increase in the groups which were treated with CZ extract.

Conclusions: The results of the present research showed that the hydroalcoholic extract of CZ has a benefcial effect on regulating the plasma levels of testosterone, estradiol, LH, FSH, FBS, and insulin in the palliation of PCOS complications.

 

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