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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2020, Vol 7, Issue 1
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New Therapies For Melanoma Cancer Strategies
Dawood Agamohammadi1, Morteza Delkhosh Reihan1, Zahra Payandeh2, Haleh Farzin1, Marzieh Marahem3
1Department of Anesthesiology, Tabriz university of medical sciences, Tabriz, Iran
2Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine Zanjan University of Medical Sciences, Zanjan Iran
3Department of Medicine Physiology, Tabriz University of medical sciences, Tabriz, Iran

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Keywords : Monoclonal Antibody, Melanoma Cancer, mRNA Vaccines, Palliative Care
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Objectives: Melanoma is the most common and severe type of skin cancer. Patients with melanoma may be undergo surgery, chemotherapy, biological therapy (immunotherapy and cancer vaccine designation), radiation therapy, a combination of these regimens, or at any stage to relieve and control of pain and other symptoms of malignancy, reduce the side effects of treatment approaches and emotional and practical problems that are treated by managing symptoms of illness, supportive care, or so -called palliative care. Some of the therapeutic strategies are application of immunotherapy and design of a cancer vaccine which can activate active immune response by stimulation of T-cells and also reduces tumor volume and size. Consequently, it creates the memory of immunity. One of the main causes of cancer immunotherapy is T lymphocyte cytotoxicity in cancer. The next strategy is to use immunotherapies (monoclonal antibodies), including antibodies against CD20, CD40, CTLA-4 and PD-1 antigens.

Materials and Methods: This study was reviewed by using a search of keywords including mRNA Vaccination, monoclonal Antibody, melanoma, and CD20 antigen in Google Scholar, PubMed , ISI web of science and Elsevier databases. Approximately 60 articles were selected that were thoroughly examined.

Results: Our study revealed that vaccine CD,Monoclonal antibodies are treatments for melanoma cancer.

Conclusion: mRNA plays a key role as a biological treatment of melanoma; a vector for tumor antigens and stimulator for inducing antitumor immune responses. In this regard, the study groups use strategies based on mRNA encoding of  entire mRNA tumor in both in vivo and in vitro environments, as well as the use of anti-CD20 antibodies with activator and inhibitors of immunosuppressive agents have been successful, and surveys in this area have focused on this.


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