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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2019, Vol 6, Issue 1
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Case Report
A Single-Case Experimental Design to Study the Combination of Cognitive-Behavioral Therapy and Pharmacotherapy for Smoking Cessation
Bijan Pirnia1,2, Maryam Akhondi3, Kambiz Pirnia4, Parastoo Malekanmehr5, Sima Farzaneh6, Kosar Deilam1, Mozhdeh Bazargan7, Leila Komeilizadeh8, Alireza Zahiroddin9
1Department of Psychology, Faculty of Humanities, University of Science and Culture, Tehran, Iran
2Behavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Islamic Azad University Branch of Kerman, Kerman, Iran
4Bijan Center for Substance Abuse Treatment, Tehran, Iran
5Islamic Azad University Branch of Hamedan, Hamedan, Iran
6Islamic Azad University Branch of Ardabil, Ardabil, Iran
7Islamic Azad University Branch of Zanjan, Zanjan, Iran
8Department of Psychology, Faculty of Psychology and Social Sciences, Islamic Azad University Roudehen Branch, Roudehen, Iran
9Department of Psychiatry, Behavior Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran

CJMB 2019; 6: 136-139

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Keywords : Cognitive-behavioral therapy, Bupropion, Smoking cessation
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Bupropion is an anti-depressant drug which is a category of aminoketones. It is a norepinephrine-dopamine inhibitor, which is considered as a nicotine antagonist and is effective in smoking cessation. The patient was a single 21-year-old girl and she was a student and had been referred to Bijan Addiction Treatment Clinic in Tehran with a complaint of chronic smoking. After a period of abstinence from consumption, she experienced anhedonia syndrome and recurrence of consumption. Data were collected from October to February 2016. We used a reversal (ABAB) design with multiple baselines, in which A was the baseline and B was the intervention phase. The entire course was 12 weeks, during which bupropion was presented. In the baseline A1 and A2, only bupropion was presented, and in B1 and B2 stages, in addition to bupropion, cognitive-behavioral therapy (CBT) was also presented. Cigarette Cravings Index and Heaviness of Smoking Index (HSI) were completed at 24 time points by the subjects. Data were analyzed by semi-parametric test of generalized estimation equation. Data analysis indicated that the addition of CBT to bupropion was associated with a significant reduction in the scores of HSI and Cigarette Cravings Index compared to bupropion alone (P<0.01). These findings can reflect the role of complementary psychological interventions in the treatment of addiction and suggest a promising perspective in linking biological and cognitive indices in response to the addiction challenge.

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Articles by Pirnia B
Articles by Akhondi M
Articles by Pirnia K
Articles by Malekanmehr P
Articles by Farzaneh S
Articles by Deilam K
Articles by Bazargan M
Articles by Komeilizadeh L
Articles by Zahiroddin A


Articles by Bijan Pirnia
Articles by Maryam Akhondi
Articles by Kambiz Pirnia
Articles by Sima Farzaneh
Articles by Kosar Deilam
Articles by Mozhdeh Bazargan
Articles by Leila Komeilizadeh
Articles by Alireza Zahiroddin

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