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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2020, Vol 7, Issue 1
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Original Article
Association of Ki67 Antigen with Mitotic Count, Tumor Size and Necrosis in Neuroendocrine Tumors of Lung
Monireh Halimi1, TaranehGhorbani1, Ali Dastranj Tabrizi1, Zhila Khamnian2, Sajjad Pourasghary3
1Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Community Medicine, National Public Health Management Centre (NPMC), Tabriz University of Medical Sciences, Tabriz, Iran
3Student Research Committee, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

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Keywords : Ki67, Neuroendocrine Lung Tumor, Metastasis, Tumor Grading
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Objectives: Lung cancer is the most common cancer in the world and one of the five most common cancers in Iran. The level of Ki67 biomarker is related to any of the factors affecting the grading of the neuroendocrine lung tumors, which is used as one of the grading criteria and also a criterion for assessing and predicting survival and prognostic factors.The aim of this project was to investigate the relationship between Ki67 antigen incidence and mitotic count, necrosis, tumor size in neuroendocrine tumors of lung.

Materials and Methods:In this analytical descriptive study samples were chosen from Imam Reza Hospital’s pathology archive from last 10 years and all samples were neuroendocrine tumors of lung in paraffin blocks. Ki67 antigen IHC procedures and mitotic count and necrosis were done by collaborator pathologist. Collected data were analyzed by SPSS 17 Software and p value for signification was considered less than 0.05 as statistically significant.

Results: The mean incidence of Ki67 antigen in neuroendocrine tumors of lung was 57.7±6.5 percent; the lowest incidence was one percent and the highest was 90 percent. The relationship between Ki67 antigen incidence and mitotic count and necrosis were significant. The relationship between Ki67 antigen incidence and tumor size in Typical Carcinoid Tumors was not significant.

Conclusion: According to the results of the study, it can be concluded that the Ki67 antigen was a useful and essential tool for grading of neuroendocrine lung tumors.


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