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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2020, Vol 7, Issue 1
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Original Article
Evaluation of Expression of CD44 and Claudin-1 Markers By Immunohistochemically Methods in Differentiation Between MCD and Focal Segmental Glomerulosclerosis (FSGS)
Tala Pourlak1, Massomeh Movahed1, Heydarali Esmaeli1
1Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran

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Keywords : Minimal change disease, Focal segmental glomerulosclerosis, Claudin-1, CD44
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Objectives:The present study aimed to examine the expression of CD44 and Claudin-1 markers using immunohistochemical methods to differentiate patients with MCD from those afflicted with FSGS.

Materials and Methods: In this descriptive-analytical study, twenty patients with definite FSGS, twenty patients with FSGS/MCD spectrum, and seven patients with definite MCD were randomly chosen from Imam Reza Hospital affiliated with the University of Tabriz Medical Sciences. All patients underwent renal biopsy, and then the presence of the immune complex was examined in obtained samples using immunofluorescence staining. Some renal specimens were paraffin-embedded for the evaluation of the expression levels of CD44 and Claudin-1 utilizing the immunohistochemistry method.

Results: Among twenty samples obtained from patients with definite FSGS, 13 samples (65%) were double-positive for CD44 and Claudin-1, 3 specimens (15%) were positive for only Claudin-1, and 4 samples (20%) were double-negative for CD44 and Claudin-1. The percentages of renal specimens expressing Claudine-1in patients with definite FSGS, FSGS/MCD, and MCD were 80%, 85%, and 0%, respectively.The percentages of renal samples expressing CD44 in patients with definite FSGS, FSGS/MCD, and MCD were 65%, 10%, and 0%, respectively.

Conclusion: The present research indicates that the rate of CD44-positive specimens was higher in patients with FSGS, while the percentage of Claudin-1-positive samples was more frequent in MCD patients compared with FSGS patients.


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