|Exon 2 Vitamin D Receptor (Fok-I) Gene Polymorphism and the Evaluation of its Correlation With Renal Dysfunction in Patients With β-Thalassemia Major in East Azerbaijan Province of Iran|
|Malihe Najafpour1, Majid Farshdousti Hagh2, Ako Azimi3, Milad Zadi Heydarabad4, Peyman Balekdari5, Aylin Jahanban Esfahlan6, Amin Ghasemi7, Saiedeh Ganbarjeddi8|
|1Medical Biotechnology Research Center, Paramedical School of Langroud, Guilan University of Medical Sciences, Rasht, Iran
2Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Basic Sciences, Maragheh University of Medical Sciences, Maragheh, Iran
4Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
5Razi Hospital of Baneh, Kurdistan University of Medical Sciences, Sanandaj, Iran
6Department of Nursing, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran
7Student Research Committee, Maragheh University of Medical Sciences, Maragheh, Iran
8School of medicine, Karazin Kharkiv National University, Kharkiv, Ukraine
CJMB 2020; 7: 393-397
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Keywords : Vitamin D receptor, Fok-I polymorphism, Thalassemia, Renal insufficiency
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Objectives: Several studies have shown that major beta-thalassemia patients suffer from renal dysfunction. Genetic is one of the crucial factors in this phenomenon. Accordingly, this study aimed to evaluate the correlation between renal dysfunction and Fok-I polymorphism in the vitamin D receptor (VDR) gene of major beta-thalassemia patients.
Materials and Methods: Sixty thalassemic patients and sixty healthy individuals were involved in this case-control study. Robust renal and urine analyzes were done in terms of performance evaluation. Finally, genotype assessment for Fok-I polymorphism was performed via the polymerase chain reaction-restriction fragment length polymorphism method.
Results: In general, renal dysfunction embracing proteinuria and hyperfilteration were observed in the thalassemic group. As regards patients" genotype frequencies, 51.6%, 36.6%, and 11.6% were homozygous for F allele (FF), heterozygous (Ff), and homozygous for f allele (ff), respectively. Eventually, the frequencies of FF and Ff alleles were 49.1% and 50.8%, respectively, in normal group l.
Conclusions: Our data suggested that there is no correlation between renal dysfunction and Fok-I polymorphism in major beta-thalassemic patients. Thus, further studies are needed about plausible pathways involved in renal dysfunction, to demonstrate the motives of renal dysfunction in major beta-thalassemia patients.
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