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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2023, Vol 10, Issue 3
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Original Article
Effect of Vitamin D Supplementation on Cardio-metabolic Indices and the Severity of Symptoms in Male Patients With Chronic Schizophrenia
Parinaz Kalejahi1, Sorayya Kheirouri1, Seyed Gholamreza Noorazar2
1Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2023; 10: 125-131
DOI: 10.34172/cjmb.2023.21
Viewed : 1143 times
Downloaded : 1288 times.

Keywords : Schizophrenia, Cardio-metabolic indices, Cardiovascular disease, PANSS, Severity
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Objectives: Hypovitaminosis D is suggested to be related to the high risk of metabolic disorders and symptoms of schizophrenia. Therefore, this study aimed to evaluate the effect of vitamin D supplementation on cardio-metabolic indices and the severity of symptoms in schizophrenic patients.

Materials and Methods: Patients with schizophrenia (N = 42) were randomly assigned to 2 groups, i.e., intervention (2000 IU of vitamin D daily; n = 21) and placebo groups (n = 21). The intervention was administered for 8 weeks. Anthropometric, clinical, and laboratory measures were assessed at both baseline and end of the trial. The Positive and Negative Syndrome Scale (PANSS) was performed to assess the schizophrenia symptoms.

Results: Vitamin D supplementation leads to a significant decrease in low-density lipoprotein cholesterol (LDL-C) levels (P = 0.006). In addition, a significant improvement was found in the PANSS negative subscale score (PANSS-NSS) and PANSS total score (PANSS-TS; P = 0.005 and P = 0.015, respectively). At the baseline, there was a significant negative correlation between PANSS-NSS, PANSS positive subscale score (PANSS-PSS), and PANSS-TS with serum levels of vitamin D (r = -0.42, P = 0.010; r = -0.34, P = 0.041; and r = -0.47, P = 0.004, respectively).

Conclusions: Vitamin D supplementation may have helpful efficacy on some cardio-metabolic indices and schizophrenia severity.


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