Efficacy of Chamomile-Lemon Balm Syrup in Patients With Conventional Drug-Resistant Cardiac Syndrome X: A Single-Arm Clinical Trial

Samaneh Noroozi; Mehrdad Karimi; Ali Vasheghani Farahani; Negar Omidi; Arman Zargaran; Samaneh Soleymani; Farshid Alaeddini; Hossein Rezaeizadeh

doi:10.34172/cjmb.2023.12

E-ISSN : 2148-9696

Crescent Journal of
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Original Article
Efficacy of Chamomile-Lemon Balm Syrup in Patients With Conventional Drug-Resistant Cardiac Syndrome X: A Single-Arm Clinical Trial
Samaneh Noroozi¹, Mehrdad Karimi¹, Ali Vasheghani Farahani², Negar Omidi², Arman Zargaran³, Samaneh Soleymani³, Farshid Alaeddini⁴, Hossein Rezaeizadeh¹
¹Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran ²Department of cardiology, Cardiac Primary Prevention Research Center, Tehran heart center, Tehran University of Medical Sciences, Tehran, Iran ³Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran ⁴Research Center for Health Management in Mass Gathering, Red Crescent Society of the Islamic Republic of Iran, Tehran, Iran
CJMB 2023; 10: 073-080 DOI: 10.34172/cjmb.2023.12 Viewed : 1193 times Downloaded : 1063 times. Keywords : Cardiac syndrome X, Matricaria chamomilla L., Melissa Officinalis L.
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Abstract

Objectives: Treatment of cardiac syndrome X (CSX) remains a major challenge for conventional medicine. In this regard, developing new natural treatments could be an alternative choice. This study was planned to appraise the efficacy of chamomile-lemon balm syrup on chest pain and quality of life in patients with conventional drug-resistant CSX. Materials and Methods: 29 participants with conventional drug-resistant were enrolled in a single-arm clinical trial, and 14 participants completed the study protocol. Chamomile (Matricaria chamomilla L.)-lemon balm (Melissa officinalis L.) syrup was provided for the treatment for the 90-day study period. All conventional treatments of CSX remained unchanged. Efficacy assessment included Seattle Angina Questionnaires (SAQ), 36-item short form survey, and the Hospital Anxiety and Depression Scale (HADS). Results: An improvement was observed in the total score of all questionnaires with statistically significant changes over time of the study (P < 0.001). Conclusions: Chamomile-lemon balm syrup showed promising results in improving effect on angina symptoms, quality of life, and anxiety and depression in the patients with drug-resistant CSX. However, a placebo-controlled trial should be performed to verify these data.