|Efficacy of Chamomile-Lemon Balm Syrup in Patients With Conventional Drug-Resistant Cardiac Syndrome X: A Single-Arm Clinical Trial|
|Samaneh Noroozi1, Mehrdad Karimi1, Ali Vasheghani Farahani2, Negar Omidi2, Arman Zargaran3, Samaneh Soleymani3, Farshid Alaeddini4, Hossein Rezaeizadeh1|
|1Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of cardiology, Cardiac Primary Prevention Research Center, Tehran heart center, Tehran University of Medical Sciences, Tehran, Iran
3Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Research Center for Health Management in Mass Gathering, Red Crescent Society of the Islamic Republic of Iran, Tehran, Iran
CJMB 2023; 10: 073-080
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Keywords : Cardiac syndrome X, Matricaria chamomilla L., Melissa Officinalis L.
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Objectives: Treatment of cardiac syndrome X (CSX) remains a major challenge for conventional medicine. In this regard, developing new natural treatments could be an alternative choice. This study was planned to appraise the efficacy of chamomile-lemon balm syrup on chest pain and quality of life in patients with conventional drug-resistant CSX.
Materials and Methods: 29 participants with conventional drug-resistant were enrolled in a single-arm clinical trial, and 14 participants completed the study protocol. Chamomile (Matricaria chamomilla L.)-lemon balm (Melissa officinalis L.) syrup was provided for the treatment for the 90-day study period. All conventional treatments of CSX remained unchanged. Efficacy assessment included Seattle Angina Questionnaires (SAQ), 36-item short form survey, and the Hospital Anxiety and Depression Scale (HADS).
Results: An improvement was observed in the total score of all questionnaires with statistically significant changes over time of the study (P < 0.001).
Conclusions: Chamomile-lemon balm syrup showed promising results in improving effect on angina symptoms, quality of life, and anxiety and depression in the patients with drug-resistant CSX. However, a placebo-controlled trial should be performed to verify these data.
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