The Association Between Helicobacter pylori Infection With Different Types of Colon Cancer and Children's Diseases: An Overview of Meta-analyses

Bahar Banasaz; Sara Saadat; Davood Kalantar-Neyestanaki; Hossein Zarrinfar; Fahimeh Shakeri; Mahmood Barani; Reza Mohammadinejad; Firoozeh Mirzaee; Masumeh Ghazanfarpour

doi:10.34172/cjmb.2023.29

E-ISSN : 2148-9696

Crescent Journal of
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The Association Between Helicobacter pylori Infection With Different Types of Colon Cancer and Children's Diseases: An Overview of Meta-analyses
Bahar Banasaz¹, Sara Saadat², Davood Kalantar-Neyestanaki³, Hossein Zarrinfar⁴, Fahimeh Shakeri⁵, Mahmood Barani⁶, Reza Mohammadinejad⁷, Firoozeh Mirzaee⁸, Masumeh Ghazanfarpour⁸
¹Babol University of Medical Sciences, Babol, Iran ²Department of Pediatric, Division of Nephrology, Dr Sheikh Hospital, Mashhad University of Medical Sciences, Mashhad Iran ³Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran ⁴Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ⁵Shiraz University of Medical Sciences, Shiraz, Iran ⁶Department of Medical Microbiology (Bacteriology and Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran ⁷Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran ⁸Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
CJMB 2023; 10: 153-160 DOI: 10.34172/cjmb.2023.29 Viewed : 1161 times Downloaded : 1030 times. Keywords : Helicobacter pylori infection, Colon cancer, Children, Meta-analysis
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Abstract

Objectives: Helicobacter pylori is a gram-negative curved bacillus that assumes a significant role in colon cancer and children´s diseases. This study aimed to examine the association between H. pylori infection with colon cancer and children´s diseases in order to achieve a a comprehensive understanding of these associations and for future works. Methods: Three main databases (i.e., Cochrane Central Register of Controlled Trials [CENTRAL], Scopus, and MEDLINE) were systematically searched by two reviewers from their inception date to 2022 in order to determine the association between the H. pylori infection with the colon cancer and children's diseases. Results: The findings of two meta-analyses were similar regarding the positive association between the risks of colorectal neoplasm (pooled OR=0.18; 95% CI of 0.99–1.40; P > 0.05) and colon neoplasia (pooled OR=0.41; 95% confidence interval 1.24–1.60; P=0.000). H. pylori was associated with an increased risk of colorectal adenoma, adenocarcinoma, and advanced adenoma. Also H. pylori infection was correlated with a high risk of iron deficiency anemia (IDA), otitis media with effusion (OME), Henoch-Schonlein purpura, and growth disorders in children. Conclusions: In sum, the H. pylori infection may have been associated with an increased risk of colorectal cancer and children's diseases.