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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2025, Vol 12, Issue 1
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Original Article
Evaluating Nanocurcumin's Influence on Human Papillomavirus Clearance and Cervical Smear Diagnostic Accuracy in High-Risk HPV Patients: A Randomized Clinical Trial
Somayeh Nikfar1, Behzad Khansarinejad2, Maryam Mohsenikia1, Reyhane Najafi3, Amir Almasi-Hashiani4, Zahra Hajmohammadhoseini1
1Department of Obstetrics and Gynecology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
2Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
3Occupational Medicine Specialist, Tehran, Iran
4Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran

DOI: 10.34172/cjmb.2024.3013
Viewed : 250 times
Downloaded : 412 times.

Keywords : Cervical cancer, Human papilloma virus (HPV), Clearance, Nanocurcumin
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Abstract
Objectives: Human papilloma virus (HPV) is the primary cause of cervical cancer, and its prevention is crucial in reducing the risk of developing this cancer. To explore potential preventive measures, we conducted a double-blind randomized clinical trial aiming at investigating the impact of oral nanocurcumin on HPV infection clearance in women who had high-risk results from HPV genotyping.

Materials and Methods: We enrolled women with high-risk HPV test results as participants in this study. Through a random assignment process, the participants were divided into two groups: one group received oral nanocurcumin (80 mg/d) along with standard treatment, while the other group received a placebo and standard treatment. The duration of the treatment period was 4 months. HPV clearance was the primary outcome measure, and we also closely monitored and recorded any adverse effects experienced by the patients as the secondary outcome.

Results: In the intervention group, we observed an HPV clearance rate of 75.0%, compared to 42.8% in the placebo group. This difference was statistically significant, with a P value of 0.026, indicating a beneficial effect of oral nanocurcumin in promoting HPV clearance. For specific HPV subtype 16, the clearance rate was higher in the nanocurcumin intervention group (71.4%) compared to the placebo group (50.0%). Similarly, for HPV subtype 18, the nanocurcumin intervention group showed a clearance rate of 77.8%, while the placebo group had a clearance rate of 37.5%. Although the sub-group analysis did not yield statistically significant differences (P > 0.05), the observed difference indicated a potential beneficial effect of nanocurcumin.

Conclusions: Our study suggests that oral nanocurcumin has the potential to enhance HPV infection clearance. Furthermore, the treatment with oral nanocurcumin appears to be safe, as we observed minimal major adverse events reported during the study period.

 

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Aras Part Medical International Press Editor-in-Chief
Arash Khaki
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Zafer Akan
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