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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2024, Vol 11, Issue 4
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Original Article
Obstetrics and Fertility Prognosis of Patients With Ovarian Granulosa Cell Tumors: A Retrospective Study in Northwest Iran
Vahideh Rahmani1, Elham Shahhosseini1, Manizheh Sayyah-Melli1, Hosein Azizi1, Maryam Vaezi1, Mehri Jafari1, Parvin Mostafa-Gharabaghi1
1Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2024; 11: 215-220
DOI: 10.34172/cjmb.2024.3018
Viewed : 185 times
Downloaded : 174 times.

Keywords : Ovarian granulosa cell tumors, Prognosis, Survival
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Abstract
Objectives: Ovarian granulosa cell tumors (GCT) are rare tumors with a late recurrence and a good prognosis. The current study investigated the fertility and obstetrics situation, survival, and the factors influencing the mortality of patients with these uncommon ovarian neoplasms.

Materials and Methods: This is a retrospective study on ovarian GCT patients admitted to the Al-Zahra hospital oncology department, the tertiary referral hospital in Tabriz, between 2009 and 2022. Data were collected from medical records. Chi-square/Fisher exact tests and t tests were used to compare categorical and quantitative variables between the alive and dead patients, respectively. The Kaplan-Meier curve was used to present patients" survival.

Results: The study involved 65 patients with ovarian GCT. The presence of ovarian cysts statistically increased the survival of GCT patients (P = 0.028). The advanced tumor stage (P = 0.023), fast tumor growth (P = 0.001), and tumor relapse (P = 0.001) are significantly correlated with mortality in the affected patients. However, age and adjuvant chemotherapy were not associated with survival.

Conclusions: There was no evidence of increased survival with the use of adjuvant chemotherapy. Tumor staging is an important prognostic factor. Advanced stages were associated with inferior survival, and only prospective studies can ascertain their definite role.

 

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