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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2017, Vol 4, Issue 4
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Original Article
The Relations Between Anti-Toxoplasma IgG and IgM Antibodies With Avidity Index
Saeedeh Shojaee1, Amir Hossien Rahbari1, Hossien Keshavarz1
1Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

CJMB 2017; 4: 177–179

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Keywords : Toxoplasma gondii, IgG, IgM, Avidity
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Objective: Toxoplasma gondii is one of the obligatory intracellular protozoan parasite with worldwide distribution. Diagnosis of acute infection is of importance in pregnancy due to congenital infection and its sequels. One of the tools for distinguishing acute from chronic infection is avidity ELISA method. This study was performed to evaluate the correlation between IgG and IgM antibodies and the of avidity index (AI).

Materials and Methods: A total of 100 serum samples were collected from different laboratories, with detectable anti-T. gondii IgG and IgM antibodies. Avidity IgG ELISA method was performed and AI was calculated.

Results:In the present study no relation between IgG concentration and the mean of AI was observed. The relation between the means of AI and concentrations of IgM antibody in 98% of acute sera was reverse.

Conclusion: Irrespective to titers of IgG and IgM antibodies, IgG avidity ELISA test could distinguish acute from chronic phase of T. gondii infection.


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