Methods: This review was reported in accordance with PRISMA 2020. PubMed, Scopus, and Web of Science were searched for English-language, peer-reviewed studies published between January 2000 and October 2025. Eligible studies evaluated adult men receiving a nonpharmacological mind-body or psychosexual intervention and reported a male sexual-health outcome. Randomized trials and prospective intervention studies, including feasibility/pilot studies, were eligible. Mixed-sex studies were eligible only when male sexual outcomes were separately extractable. Risk of bias was assessed using RoB 2 for randomized trials and the JBI quasi-experimental tool for uncontrolled intervention studies; certainty was summarized using GRADE principles.

Results: After reappraisal of eligibility, four studies were retained. Interventions included psychosexual education, mindfulness-based group therapy, mindfulness-based couple therapy after prostate cancer, and a 12-week app-based multimodal program. Psychosexual education improved sexual assertiveness and reduced fear of intercourse. A small uncontrolled mindfulness pilot suggested moderate improvement in erectile function and a large improvement in sexual satisfaction. The app-based randomized trial reported an increase in IIEF-5 score of 4.5 points versus 0.2 in the waiting-list group (P<0.0001), along with improvements in disease-related quality of life and patient activation. The evidence was too heterogeneous for meta-analysis, and certainty ranged from very low to low.

Conclusions: Mind-body and psychosexual interventions may improve selected male sexual-health outcomes, particularly erectile function, sexual satisfaction, and psychosexual confidence. However, the small number of studies, methodological limitations, heterogeneity, and restricted search coverage preclude firm conclusions about efficacy. Larger preregistered randomized trials using standardized sexual outcomes are needed.